Tag: research

Notice: Trying to get property of non-object in /home/allabouthabits/public_html/wp-content/plugins/enhanced-category-pages/classes/ecp/Enhanced_Category.php on line 143

Notice: Undefined offset: 0 in /home/allabouthabits/public_html/wp-content/plugins/enhanced-category-pages/classes/ecp/Enhanced_Category.php on line 232

Notice: Trying to get property of non-object in /home/allabouthabits/public_html/wp-includes/post-template.php on line 298

Notice: Trying to get property of non-object in /home/allabouthabits/public_html/wp-content/plugins/thrive-apprentice/inc/classes/class-tva-settings.php on line 402

Notice: Trying to get property of non-object in /home/allabouthabits/public_html/wp-content/plugins/thrive-apprentice/inc/classes/class-tva-settings.php on line 402

Notice: Trying to get property of non-object in /home/allabouthabits/public_html/wp-content/plugins/all-in-one-schemaorg-rich-snippets/functions.php on line 56

It’s no secret that obesity is harmful to health, and recent studies have debunked the myth that one can be “fat but fit.”

Also well-established is the link between obesity and increased cancer risk, but how it actually causes cancer has yet to be fully explained.

A recent study offers more details on the association. Researchers at Michigan State University found that a certain protein released from fat in the body can cause a non-cancerous cell to turn into a cancerous one.

The research also found that a lower layer of abdominal fat, when compared to fat just under the skin, is the more likely culprit, releasing even more of this protein and encouraging tumor growth.

It is estimated that at least one third of the population is obese. Obesity has been linked to several types of cancers including breast, colon, prostate, uterine, and kidney.

But Jamie Bernard, the study’s lead author and an assistant professor in pharmacology and toxicology, said that just being overweight isn’t necessarily the best way to assess risk:

“Our study suggests that body mass index, or BMI, may not be the best indicator. It’s abdominal obesity, and even more specifically, levels of a protein called fibroblast growth factor-2 that may be a better indicator of the risk of cells becoming cancerous.”

There are two layers of belly fat. The top layer, known as subcutaneous fat, lies right under the skin. The layer under that, called visceral fat, is the one she found to be more harmful.

In the article Do You Need a Reason to Stop Drinking Soda? Here it Is, I explained what visceral fat is and why it is so dangerous:

Visceral fat – also known as “deep fat” – wraps around your internal organs, including your liver, pancreas, kidneys, and intestines. It is much more dangerous than subcutaneous fat (the fat that you can see – the “inch you can pinch”). That’s because visceral fat (which gets its name from viscera, which refers to the internal organs in the abdomen) affects how our hormones function and is thought to play a larger role in insulin resistance – which may increase Type 2 diabetes and heart disease risk.

Excess visceral fat is also linked to an increased risk of developing cancer, stroke, dementia, depression, arthritis, obesity, sexual dysfunction, and sleep disorders.

You don’t have to be visibly overweight to be at risk. Even relatively thin people can have too much visceral fat, which is why it is often referred to as “hidden” belly fat.

Back to the study.

Here’s how Bernard and her team conducted their research:

Bernard and her co-author Debrup Chakraborty, a postdoctoral student in her lab, studied mice that were fed a high-fat diet and discovered that this higher-risk layer of fat produced larger amounts of the fibroblast growth factor-2, or FGF2, protein when compared to the subcutaneous fat. They found that FGF2 stimulated certain cells that were already vulnerable to the protein and caused them to grow into tumors.

She also collected visceral fat tissue from women undergoing hysterectomies and found that when the fat secretions had more of the FGF2 protein, more of the cells formed cancerous tumors when transferred into mice. (source)

What does this mean?

Bernard explains,

“This would indicate that fat from both mice and humans can make a non-tumorigenic cell malignantly transform into a tumorigenic cell.”

There are several other factors released from fat, Bernard said, including the hormone estrogen, that could influence cancer risk, but many of those studies have only been able to show an association and not a direct cause of cancer. She added that genetics also play a role.

“There’s always an element of chance in whether a person will get cancer or not. But by making smarter choices when it comes to diet and exercise and avoiding harmful habits like smoking, people can always help skew the odds in their favor.”

The study is published in the journal Oncogene and was funded by the National Institutes of Health.

***

Related Reading

Obesity Can Significantly Shorten Your Life, and You Really Can’t be “Fat But Fit”

Do You Need a Reason to Stop Drinking Soda? Here It Is.

Cancer, the Media, and the Misinterpretation of Studies: A Cautionary Tale

Disclaimer

Nutritional Anarchy is owned and operated by Lisa Egan and may contain advertisements, sponsored content, paid insertions, affiliate links or other forms of monetization.

Nutritional Anarchy abides by word-of-mouth marketing standards. We believe in honesty of relationship, opinion, and identity. The compensation received may influence the advertising content, topics, or posts made in this blog. That content, advertising space, or post will be clearly identified as paid or sponsored content.

Nutritional Anarchy is never directly compensated to provide opinion on products, services, websites, and various other topics. The views and opinions expressed on this website are purely those of the authors. If we claim or appear to be experts on a certain topic or product or service area, we will only endorse products or services that we believe, based on our expertise, are worthy of such endorsement. Any product claim, statistic, quote, or other representation about a product or service should be verified with the manufacturer or provider.

This site does not contain any content which might present a conflict of interest.

Nutritional Anarchy makes no representations, warranties, or assurances as to the accuracy, currency, or completeness of the content contain on this website or any sites linked to or from this site.

Nutritional Anarchy may offer health, fitness, nutritional, and other such information, but such information is designed for educational and informational purposes only. The information contained on the site does not and is not intended to convey medical advice and does not constitute the practice of medicine. You should not rely on this information as a substitute for, nor does it replace, professional medical advice, diagnosis, or treatment. Nutritional Anarchy is not responsible for any actions or inaction on a user’s part based on the information that is presented on the site.


Notice: Trying to get property of non-object in /home/allabouthabits/public_html/wp-includes/comment-template.php on line 1200

Belly Fat Really is a Killer: Here’s How it Can Increase Your Cancer Risk

Researchers at Michigan State University found that a certain protein released from fat in the body can cause a non-cancerous cell to turn into a cancerous one.

Obesity Can Significantly Shorten Your Life, and You Really Can’t be “Fat But Fit”

Two recent studies on obesity yielded some concerning findings regarding its impacts on life expectancy and heart disease.

Let’s take a look at each.

Obesity and Longevity

In April, researchers from the Cleveland Clinic and New York University School of Medicine found that obesity resulted in as much as 47 percent more life-years lost than tobacco, and tobacco caused similar life-years lost as high blood pressure.

The research team found the greatest number of preventable life-years lost were due to (in order from greatest to least) obesity, diabetes, tobacco use, high blood pressure, and high cholesterol.

Of the five top causes of death, three (diabetes, hypertension, and high cholesterol) are treatable with medications and lifestyle changes. Obesity and tobacco use are more challenging issues to resolve: both involve complex psychological factors.

From the press release:

To estimate the number of life-years lost to each modifiable risk factor, researchers examined the change in mortality for a series of hypothetical U.S. populations that each eliminated a single risk factor. They compared the results with the change in life-years lost for an “optimal” population that eliminated all modifiable risk factors. Recognizing that some less common factors might place substantial burden on small population subgroups, they also estimated life expectancy gained in individuals with each modifiable risk factor.

The reality is, while we may know the proximate cause of a patient’s death, for example, breast cancer or heart attack, we don’t always know the contributing factor(s), such as tobacco use, obesity, alcohol and family history. For each major cause of death, we identified a root cause to understand whether there was a way a person could have lived longer.

Glen Taksler, Ph.D., internal medicine researcher from Cleveland Clinic and lead author of the study, said of the findings,

“Modifiable behavioral risk factors pose a substantial mortality burden in the U.S. These preliminary results continue to highlight the importance of weight loss, diabetes management and healthy eating in the U.S. population.”

***

Busting the “Fat but Fit” Myth

Storing too much fat in the body is associated with a number of metabolic changes, including increased blood pressure, high blood sugar, and altered cholesterol levels, which have been linked to numerous health problems and diseases.

However, some studies have revealed a subset of overweight people who appear to lack the adverse health effects of excess weight, leading to them being classified as “metabolically healthy obese” in the medical literature (referred to “fat but fit” in the media).

In August, researchers from Imperial College London, University College London, and other institutions across Europe found that being overweight or obese increases a person’s risk of coronary heart disease (CHD) by up to 28 percent compared to those with a healthy bodyweight – even if they have healthy blood pressure, blood sugar, and cholesterol levels.

For this study – the largest of its kind to date – scientists used data from more than half a million people in 10 European countries – taken from the European Prospective Investigation into Cancer and Nutrition (EPIC). They found that excess weight is linked with an increased risk of heart disease, even when people have a healthy metabolic profile. Researchers focused on weight and signs of heart disease. Then, they looked at more than 7,637 people who had cardiovascular events such as death from heart attack, and compared them to more than 10,000 people who didn’t have heart problems.

Being metabolically unhealthy or having metabolic syndrome was defined as having three or more of the following at baseline:

  • high blood pressure, use of blood pressure medications, or self-reported history
  • high triglycerides (a type of fat) or use of lipid-lowering medication like statins
  • low HDL (good) cholesterol
  • high blood sugar, use of diabetes medications, or self-reported history
  • high waist circumference

Researchers looked for the new development of heart disease during follow-up, either self-reported or through data from GP and hospital registers and mortality records. The last follow-up ranged from 2003- 2010, with an average of 12.2 years.

They looked at the link between body fat, metabolic markers, and developing heart disease, adjusting for baseline variables of country, gender, age, education, smoking status, alcohol intake, diet, and physical activity.

After those adjustments and considerations, the scientists found that people with three or more heart risk factors like high blood pressure, high cholesterol, or large waist sizes (more than 37 inches for men and 31 inches for women) were more than twice as likely to have heart disease, regardless of whether their weight was normal or above normal.

But those who were considered overweight yet healthy were still 26 percent more likely to develop heart disease than their normal-weight peers. Those considered healthy but obese had a 28 percent higher risk, the study found.

The findings, which were published in the European Heart Journal, add to a growing body of evidence that suggests being “fat but fit” is a myth, and that people should aim to maintain a body weight within a healthy range.

The excess weight itself may not be increasing the risk of heart disease directly, but rather indirectly through mechanisms such as increased blood pressure and high glucose, the researchers said.

Lead author Dr. Camille Lassale explained,

“Our findings suggest that if a patient is overweight or obese, all efforts should be made to help them get back to a healthy weight, regardless of other factors. Even if their blood pressure, blood sugar and cholesterol appear within the normal range, excess weight is still a risk factor.”

Dr. Ioanna Tzoulaki, from Imperial’s School of Public Health, added,

“I think there is no longer this concept of healthy obese. If anything, our study shows that people with excess weight who might be classed as ‘healthy’ haven’t yet developed an unhealthy metabolic profile. That comes later in the timeline, then they have an event, such as a heart attack.”

***

Additional Resources:

Secrets from the Eating Lab: The Science of Weight Loss, the Myth of Willpower, and Why You Should Never Diet Again by Traci Mann, PhD

Diet Anarchy: Are You Sabotaging Yourself?

Diet Anarchy: The More Things Are Forbidden…

Why You Should Ditch Your Scale

Diet Anarchy: Are You Eating Enough?

Diet Anarchy: Should You Count Calories or Eat Intuitively?

***

Disclaimer

Nutritional Anarchy is owned and operated by Lisa Egan and may contain advertisements, sponsored content, paid insertions, affiliate links or other forms of monetization.

Nutritional Anarchy abides by word-of-mouth marketing standards. We believe in honesty of relationship, opinion, and identity. The compensation received may influence the advertising content, topics, or posts made in this blog. That content, advertising space, or post will be clearly identified as paid or sponsored content.

Nutritional Anarchy is never directly compensated to provide opinion on products, services, websites, and various other topics. The views and opinions expressed on this website are purely those of the authors. If we claim or appear to be experts on a certain topic or product or service area, we will only endorse products or services that we believe, based on our expertise, are worthy of such endorsement. Any product claim, statistic, quote, or other representation about a product or service should be verified with the manufacturer or provider.

This site does not contain any content which might present a conflict of interest.

Nutritional Anarchy makes no representations, warranties, or assurances as to the accuracy, currency, or completeness of the content contain on this website or any sites linked to or from this site.

Nutritional Anarchy may offer health, fitness, nutritional, and other such information, but such information is designed for educational and informational purposes only. The information contained on the site does not and is not intended to convey medical advice and does not constitute the practice of medicine. You should not rely on this information as a substitute for, nor does it replace, professional medical advice, diagnosis, or treatment. Nutritional Anarchy is not responsible for any actions or inaction on a user’s part based on the information that is presented on the site.

No, Gluten-Free Diets Do NOT Cause Diabetes: New “Study” Has Serious Flaws

A new “study” claims that low-gluten diets may be associated with higher risk of type 2 diabetes, but red flags abound.

Why EVERYONE Should Care About the Government’s War on Cannabis and Kratom

One doesn’t have to look hard for evidence that the government does not truly care about public health – or individual liberty. The DEA’s refusal to remove cannabis from Schedule I, and it’s plan to ban kratom are two tragic examples.

Do You Need a Reason to Stop Drinking Soda? Here It Is.

Drinking sugar-sweetened beverages every day is associated with an increase in a particularly nasty type of body fat that has been linked with diabetes, heart disease risk, and a multitude of other health issues.

Cancer, the Media, and the Misinterpretation of Studies: A Cautionary Tale

Words mean things, and particularly so when translating complex scientific findings into press releases, abstracts, and articles that are meant for the general public.

Theme: Overlay by Kaira
>